UZAY
Human Research
MESSAGE
Microgravity Related Genetic Science Mission
Uskudar University
Prof. Dr. Lecturer Prof. Dr. Cihan Taştan
Büşra Tekirdağlı, Ebru Çam, Özge Demir, Gamze Gülden, Berranur Sert, Fatmanur Erkek
It is aimed to identify genes whose function has not yet been discovered and to determine which immune cells will be directly affected by gravity during space missions with CRISPR gene engineering methods.
For this purpose, blood samples were taken from the astronauts participating in the study at the time points determined before and during the flight, and transcriptome analysis was performed on these samples.
After the space mission, it was planned to apply CRISPR gene editing technologies to destroy genes in T cells that were found to be up-regulated by microgravity.
The researchers also intend to use an acoustic levitation device in ground experiments to analyze cell proliferation, survival, stress responses, changes in anti-cancer and cytokine release profiles at the cellular level.
METABOLOM
Analysis of Changes in Metabolome/Transcriptome of Astronauts on Space Missions and Creation of National Omics Data Sets
Ankara University
Prof. Dr. Emel Emregül
Oğuzhan Durmaz, Prof. Dr. Emirhan Nemutlu, Assoc. Dr. Evren Özçınar, Assoc. Dr. Burak Derkuş, Dr. Nihan Akdoğan, Dr. Cemil Can Eylem
Spaceflight is one of the most demanding physical conditions humans can experience. Astronauts are exposed to environmental stresses during space missions, such as low gravity, space radiation, altered physical activity, nutritional problems, lack of sleep, high g and hyperoxia.
Our research aims to reveal the negative effects of space conditions on human health. In addition, in order to reduce these negative effects, it is aimed to examine the physiological and biochemical changes in gene expression and metabolism of our astronauts participating in space missions under the influence of space environment conditions. With this study, it is aimed to provide new information in understanding the possible risk factors of system-wide changes in the body for the health of our astronauts, and to provide useful data for further research for experts who will work on topics such as gravity physiology, aerospace medicine in space research in our country. It is also thought to be useful in the development of new treatments and preventive measures for existing diseases on Earth.
MIYELOID
Investigation of the Effect of Radiation Exposure on Myeloid-derived Suppressor Cells in Peripheral Blood, Precursor Lesions for Cancer in Individuals Participating in Space Missions
Hacettepe University
Prof. Dr. Güneş Esendağlı
Prof. Dr. Kerim Bora Yılmaz, Assoc. Prof. Dr. Erhan Güven, Hamdullah Yanık
Myeloid-derived suppressor cells (MKBCs) are a heterogeneous population of immature myeloid cells that are produced at high levels in chronic inflammatory processes such as cancer, suppress immunosuppression and promote cancer progression and metastasis. The aim of this study was to immunologically measure and evaluate the travel and space conditions and cosmic radiation damage that space mission participants will be exposed to at the level of MKBH cells.
